ホーム 計算ツール
代理店ログイン

検索結果

Search Results for " 3T3 cells "

ターゲット

19

阻害剤

8

天然化合物

カタログ番号 製品名 別名 ターゲット
T7196 HG-10-102-01 LRRK2
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
T21312 Afatinib Afatinib free base,BIBW 2992 EGFR , Autophagy
Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively).
T1773 Afatinib Dimaleate BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate EGFR , HER , Autophagy
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act...
T11212 EPAC 5376753 5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione cAMP
T9650 AZ12672857 Src , Ephrin Receptor
AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 n...
T28740 SDZ-62-434 SDZ 62 434,SDZ62434 Platelet aggregation
SDZ-62-434 is a platelet-activating factor inhibitor with antitumor activity that inhibits bombesin- and platelet-derived growth factor-induced DNA synthesis in quiescent Swiss 3T3 cells for the study of leukemia, human ...
T9491 Pyraclostrobin Antibacterial , Antifungal
Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.
T60857 MKK7-COV-9 Others
MKK7-COV-9 is a selective and potent covalent inhibitor of MKK7 with inhibitory effects on MKK7-induced protein-protein interactions.MKK7-COV-9 interrupts the activation of primary B-cells in response to LPS.MKK7-COV-9 s...
T10849 CMLD012612 Others
T36821 FQI 1
FQI 1 is an SV40 factor (LSF) inhibitor. FQI 1 inhibits cell proliferation, with IC50s of 3, 0.79, and 6.3 μM for NIH/3T3, HeLa, and A549 cells, respectively. FQI1 could be used in cancer research.
T10848 CMLD012073 Others
T83127 AMPK activator 13 AMPK
AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygen consumption rates. This compound is utilized in the study of...
T36330 Terrecyclic Acid
Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs = 25, 50, and 25 μg/ml, respectively). Ter...
T62052 AMPK activator 6
AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase of total cholesterol (TC), low-density lipoprotein-C (...
T36542 Prostaglandin A2 Medullin
PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some anti...
T67442 CGP-53716
The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase i...
T35800 MD001
MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. ...
T35854 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a r...
T37579 GW 1929 hydrochloride
Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and tr...
カタログ番号 製品名 別名 ターゲット
T3220 Euphorbiasteroid Euphobiasteroid,Euphorbia factor L1 Others , AMPK
Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
TN1206 2,4,6-Trihydroxybenzaldehyde Others
2,4,6-Trihydroxybenzaldehyde is a natural product
T81291 Retrofractamide A
Retrofractamide A, an amide constituent extracted from Piper chaba fruit, enhances adipogenesis in 3T3-L1 cells [1].
TN5090 Tachioside Glucokinase
Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows antiobesity activities. Tachioside can inhibit nitric oxid...
TN3112 5-Heneicosylresorcinol NADPH-oxidase , Antifection
5-Heneicosylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells, it also prevents triglyceride accumulation in 3T3-L1 cells. 5-Heneicosylresorcinol has nematicidal activity against n...
TN5655 Broussonin B
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin B can induce neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, and show moderate inhibitory activities against a chymotrypsi...
TN5682 2,6,4'-Trihydroxy-4-methoxybenzophenone
2,6,4'-Trihydroxy-4-methoxybenzophenone shows weak inhibitory activity of testosterone 5alpha-reductase, it also shows significant inhibition of pancreatic lipase activity. 2,6,4'-Trihydroxy-4-methoxybenzophenone has neu...
TN3539 Broussonin A ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-lucife...